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A powerful whole organism model for detecting toxicity for the environment and human health

The challenge

For drug developers, the leap from in-vitro to in-vivo to detect the toxicity of your compounds in whole organisms is expensive and time-consuming. Traditionally, drug developers look to rodent or other mammalian models to test the developmental and reproductive toxicity of compounds but these avenues have long timelines, high costs, and lead to overly complex study designs.

For those looking at the environmental toxicity of their compounds,  there are few tried and tested options to ethically check whether your compounds will be toxic to wildlife and animals. Traditional go-to animal models like fish or rodents have ethical considerations and can involve complex study designs and take a long time to answer your toxicity research questions.

The Magnitude Biosciences approach

C. elegans are a well-characterised, ethical model for environmental toxicity testing, with good concordance to mammalian models. Our use of C. elegans combined with our unique automated technology means we can detect toxicity much more quickly than the use of other in-vivo models.

Our Healthspan assay on adult sterile worms can detect chronic effects on ageing, mobility and behaviour, but we also conduct Developmental and Reproductive Toxicity (DART) assays. With 300 progeny produced by each healthy adult worm in 3 days, we can detect acute developmental and reproductive toxicity fast and with sensitivity.

We can measure toxicity in three different study types:

Acute toxicity

  • We help you to understand if your drug causes short-term mortality for animals at high concentrations (similar to what you would see studying the impact of a single dose in rodents).

Reproductive and development toxicity

  • Using manual toxicity assays, we can generate specific measurements on the impact of compounds on development and reproduction by quantifying population growth.

Chronic toxicity

  • We help you understand the mortality impact of your drug on animals from long-term exposure at lower concentrations (similar to what you would see studying repeat doses in rodent models).
  • We can also use our healthspan assays to assess if your compounds impact the health of an animal in old age more easily and quickly than you can see in mice.

We provide the following benefits:

  • Cost and time-efficient assays for predictivity data prior to rodent models.
  • Rich, sensitive data set that goes far beyond traditional manual lifespan assays.
  • Standardised, population-scale acute and chronic testing for mutation and compound effects on both longevity and fitness.
  • Team of multidisciplinary experts to advise you on study design and data analysis.

We provide invaluable tools to accelerate R&D across different industries

Our team has rich experience helping researchers in these sectors
  • Biotech

    Take the jump from petri dish to in vivo models with confidence.

  • Health and Manufacturing

    Helping industrial R&D get the data they need on their compounds in as little as three weeks.

  • Pharma

    Fast-track your preclinical research and de-risk high-investment rodent studies.

  • Academia

    High-quality C. elegans lab services and machine leasing of our unique automated technology to help you stay top of your field.

biotech

Biotech

Biotech professionals must progress their drug discovery R&D timelines fast in order to make the best use of their funding and IP. We help you take the jump from petri dish to mammal in vivo models with confidence and more quickly than going straight to rodent models.

Find out more

biotech

Health and Manufacturing

Consumer goods, manufacturing and other industries investing in R&D want to put the best quality, eco-friendly products out on the market. However, testing your compounds for impact on environmental and human health can lead to overly complex, ethically challenging and time-consuming studies with animal models. C. elegans offer an ethical approach that can get the data you need on your compound in as little as three weeks.

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biotech

Pharma

The pressure on drug developers is greater than ever and pharma need to look to innovative new tools to stay ahead of the competition. C. elegans offer an NC3Rs-approved avenue to fast-track preclinical research, to save you from or reduce your reliance on high-investment rodent studies.

Find out more

biotech

Academia

You want to progress your research and improve lab operations but access to the right technologies, technological expertise and the time to juggle everything is challenging. We offer high-quality C. elegans lab services, transgenics services, and machine leasing of our unique automated technology to help you stay top of your field.

Find out more

Biotech

Take the jump from petri dish to in vivo models with confidence.

Health and Manufacturing

Helping industrial R&D get the data they need on their compounds in as little as three weeks.

Pharma

Fast-track your preclinical research and de-risk high-investment rodent studies.

Academia

High-quality C. elegans lab services and machine leasing of our unique automated technology to help you stay top of your field.

CONTACT US

Get in touch today to find out how we can 
support you to accelerate your research

CONTACT US

Get in touch today to find out how we can 
support you to accelerate your research
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