For drug developers, the leap from in-vitro to in-vivo to detect the toxicity of your compounds in whole organisms is expensive and time-consuming. Traditionally, drug developers look to rodent or other mammalian models to test the developmental and reproductive toxicity of compounds but these avenues have long timelines, high costs, and lead to overly complex study designs.
For those looking at the environmental toxicity of their compounds, there are few tried and tested options to ethically check whether your compounds will be toxic to wildlife and animals. Traditional go-to animal models like fish or rodents have ethical considerations and can involve complex study designs and take a long time to answer your toxicity research questions.
Read about our toxicity work with Michelin, a Fortune 500 consumer good manufacturing company and the global leader in tyre manufacturing
C. elegans are a well-characterised, ethical model for environmental toxicity testing, with good concordance to mammalian models. Our use of C. elegans combined with our unique automated technology means we can detect toxicity much more quickly than the use of other in-vivo models.
Our Healthspan assay on adult sterile worms can detect chronic effects on ageing, mobility and behaviour, but we also conduct Developmental and Reproductive Toxicity (DART) assays. With 300 progeny produced by each healthy adult worm in 3 days, we can detect acute developmental and reproductive toxicity fast and with sensitivity.
We can measure toxicity in three different study types:
Acute toxicity
Reproductive and development toxicity
Chronic toxicity
We provide the following benefits:
Biotech
Biotech professionals must progress their drug discovery R&D timelines fast in
order to make the best use of their funding and IP. We help you take the jump from
petri dish to mammal in vivo models with confidence and more quickly than going straight
to rodent models.
Health and Manufacturing
Consumer goods, manufacturing and other industries investing in R&D want to put
the best quality, eco-friendly products out on the market. However, testing your
compounds for impact on environmental and human health can lead to overly complex,
ethically challenging and time-consuming studies with animal models. C. elegans offer
an ethical approach that can get the data you need on your compound in as little as three weeks.
Pharma
The pressure on drug developers is greater than ever and pharma need to look to
innovative new tools to stay ahead of the competition. C. elegans offer an NC3Rs-approved
avenue to fast-track preclinical research, to save you from or reduce your reliance on
high-investment rodent studies.
Academia
You want to progress your research and improve lab operations but access to the
right technologies, technological expertise and the time to juggle everything is
challenging. We offer high-quality C. elegans lab services, transgenics services,
and machine leasing of our unique automated technology to help you stay top of your field.
Take the jump from petri dish to in vivo models with confidence.
Helping industrial R&D get the data they need on their compounds in as little as three weeks.
Fast-track your preclinical research and de-risk high-investment rodent studies.
High-quality C. elegans lab services and machine leasing of our unique automated technology to help you stay top of your field.