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A powerful whole organism model for microbiome research

The challenge

The microbiome holds great promise for novel drug development against chronic conditions, but the demonstrated efficacy of interventions hides a lack of mechanistic understanding about the microbes and molecular pathways involved.

  • Current Microbiome strategies show efficacy but lack mechanistic understanding.
  • Rodent or other mammalian models for animal testing for chronic effects of a large number of microbial candidates is time-consuming and expensive.

The MB approach

C. elegans-bacteria interactions make it a powerful model for dissecting the effects of single bacterial strains isolated from the human microbiome. By manipulating the bacterial lawn on which our worms are cultured, our automated Healthspan assays can test for acute and chronic effects of specific bacterial strains, extracts or conditioned media on development, mobility and ageing. We can also test compounds that change how bacteria influence animal health.

  • C. elegans have shown to be relevant to mammal/human cellular pathways and are amenable to genetic modification.
  • C. elegans have a fast experimental turnaround with a 3 day lifecycle, a 2-3 weeks lifespan and a large number of progeny.
  • It has been shown that genetic or pharmaceutical manipulation of the bacteria that are used to culture C. elegans can slow ageing.
  • We use C. elegans to detect acute and chronic effects on mobility, longevity, fertility much faster and cheaper than you can with mouse models.

We provide the following benefits:

  • Cost and time-efficient assays for predictivity data prior to rodent models.
  • Rich, sensitive data set that goes far beyond traditional manual lifespan assays.
  • Standardised, population-scale acute and chronic testing for mutation and compound effects on both ageing and fitness.
  • Team of multidisciplinary experts to advise you on study design and data.

We provide invaluable tools to accelerate R&D across different industries

Our team has rich experience helping researchers in these sectors
  • Biotech

    Take the jump from petri dish to in vivo models with confidence.

  • Health and Manufacturing

    Helping industrial R&D get the data they need on their compounds in as little as three weeks.

  • Phrama

    Fast-track your preclinical research and de-risk high-investment rodent studies.

  • Academia

    High-quality C. elegans lab services and machine leasing of our unique automated technology to help you stay top of your field.

biotech

Biotech

Biotech professionals must progress their drug discovery R&D timelines fast in order to make the best use of their funding and IP. We help you take the jump from petri dish to mammal in vivo models with confidence and more quickly than going straight to rodent models.

Find out more

biotech

Health and Manufacturing

Consumer goods, manufacturing and other industries investing in R&D want to put the best quality, eco-friendly products out on the market. However, testing your compounds for impact on environmental and human health can lead to overly complex, ethically challenging and time-consuming studies with animal models. C. elegans offer an ethical approach that can get the data you need on your compound in as little as three weeks.

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biotech

Pharma

The pressure on drug developers is greater than ever and pharma need to look to innovative new tools to stay ahead of the competition. C. elegans offer an NC3Rs-approved avenue to fast-track preclinical research, to save you from or reduce your reliance on high-investment rodent studies.

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biotech

Academia

You want to progress your research and improve lab operations but access to the right technologies, technological expertise and the time to juggle everything is challenging. We offer high-quality C. elegans lab services, transgenics services, and machine leasing of our unique automated technology to help you stay top of your field.

Find out more

Biotech

Take the jump from petri dish to in vivo models with confidence.

Health and Manufacturing

Helping industrial R&D get the data they need on their compounds in as little as three weeks.

Pharma

Fast-track your preclinical research and de-risk high-investment rodent studies.

Academia

High-quality C. elegans lab services and machine leasing of our unique automated technology to help you stay top of your field.

CONTACT US

Get in touch today to find out how we can 
support you to accelerate your research

CONTACT US

Get in touch today to find out how we can 
support you to accelerate your research
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