The microbiome holds great promise for novel drug development against chronic conditions, but the demonstrated efficacy of interventions hides a lack of mechanistic understanding about the microbes and molecular pathways involved.
C. elegans-bacteria interactions make it a powerful model for dissecting the effects of single bacterial strains isolated from the human microbiome. By manipulating the bacterial lawn on which our worms are cultured, our automated Healthspan assays can test for acute and chronic effects of specific bacterial strains, extracts or conditioned media on development, mobility and ageing. We can also test compounds that change how bacteria influence animal health.
We provide the following benefits:
Biotech
Biotech professionals must progress their drug discovery R&D timelines fast in
order to make the best use of their funding and IP. We help you take the jump from
petri dish to mammal in vivo models with confidence and more quickly than going straight
to rodent models.
Health and Manufacturing
Consumer goods, manufacturing and other industries investing in R&D want to put
the best quality, eco-friendly products out on the market. However, testing your
compounds for impact on environmental and human health can lead to overly complex,
ethically challenging and time-consuming studies with animal models. C. elegans offer
an ethical approach that can get the data you need on your compound in as little as three weeks.
Pharma
The pressure on drug developers is greater than ever and pharma need to look to
innovative new tools to stay ahead of the competition. C. elegans offer an NC3Rs-approved
avenue to fast-track preclinical research, to save you from or reduce your reliance on
high-investment rodent studies.
Academia
You want to progress your research and improve lab operations but access to the
right technologies, technological expertise and the time to juggle everything is
challenging. We offer high-quality C. elegans lab services, transgenics services,
and machine leasing of our unique automated technology to help you stay top of your field.
Take the jump from petri dish to in vivo models with confidence.
Helping industrial R&D get the data they need on their compounds in as little as three weeks.
Fast-track your preclinical research and de-risk high-investment rodent studies.
High-quality C. elegans lab services and machine leasing of our unique automated technology to help you stay top of your field.