Age-Related Cognitive Decline Assay with C. elegans | Neurodegenerative Disease Models

Age-related Cognitive Decline Assay

Measuring decline in neuronal function with age

C. elegans, with its well-mapped nervous system and neurotransmitter similarities to humans, presents a unique model for studying age-related cognitive decline. The decline in dopaminergic responses associated with ageing mirrors conditions like Parkinson’s disease (PD) in humans.

The Challenge:

Current behavioural assays using rodents for studying cognitive decline are expensive, time-consuming, and lack translatability to human conditions, hindering progress in anti-ageing therapeutic development.

Our Solution:

Magnitude Biosciences leverages C. elegans and our proprietary WormGazer™ technology to provide our novel Age-related Cognitive (ARC) Functional Decline Assay. This assay quantifies cognitive decline in aged worms and neurodegenerative disease models, offering a cost-effective and efficient alternative to rodent models.

The ARC Assay:

Our ARC assay measures cognitive function through a chemotaxis-dependent behavior that declines with age. By automating data acquisition with our WormGazer™ technology, we can evaluate the effects of compounds and disease models on cognitive health in C. elegans. Worms of various ages are placed a fixed distance from their food source. As they age, it takes longer for them to find their food, and they are less able to cognitively localise themselves to the food.

Final_Distance_From_Lawn_TransparentBackground

Worms of various ages are placed a fixed distance from their food source. As they age, it takes longer for them to find their food, and they are less able to cognitively localise themselves to the food.

Key Benefits:

Cost-Effective

Reduce research costs with our efficient C. elegans-based assays.

Time-Efficient

Rapidly assess cognition with automated technology.

Translatable

Gain insights applicable to age-related neurodegenerative conditions in humans.

Customisable

Tailor assays to specific research needs for comprehensive results.

Control

Normal mobility and exploration
Can recognise food source
Remains in contact with food

Disease A

Normal mobility and exploration
Impaired cognitive function
Failure to recognise and move towards food

Disease B

Impaired mobility and exploration
Can recognise food source
Remains in contact with food

Partner with us for Neuronal Function Research

Collaborate with Magnitude Biosciences to accelerate your research on age-related cognitive decline. Our ARC assay provides a streamlined approach to assess compound efficacy.