Cost-Effective Muscle Health Assay with C. elegans

Manual Paralysis Assay

Assess neuronal function in C. elegans

Age-related neurodegeneration, such as seen in Parkinson’s disease (PD) and Alzheimer’s, is a pressing challenge associated with the decline in neurotransmitter function. C. elegans, with its mapped nervous system and neurotransmitter similarities to humans, provides a valuable model for studying neurological health and ageing.

The Challenge:

Current methods relying on rodent models for neurobehavioral assessments are costly, time-consuming, and lack translatability to human conditions, hindering progress in neuroprotective therapeutic development.

Our Solution:

Magnitude Biosciences offers a novel approach using C. elegans, along with our patented WormGazer™ technology, to investigate age-related neurodegeneration. Leveraging the worm’s genetic and functional parallels to human neurotransmitter systems, we employ a manual paralysis assay to assess neurological function and screen potential neuroprotective compounds.

Manual Paralysis Assay:

Our proprietary manual paralysis assay evaluates the efficacy of compounds in rescuing neuronal function in C. elegans. By inducing paralysis and observing responses, we can quantify the effects of test compounds on neurotransmitter signaling and mobility.

Levamisole is an acetylcholine receptor agonist.

Control worms exhibit normal movement.

0.02 mM Levamisole slows worms and a small percentage are fully paralysed.

At the top levamisole concentration, paralysed worms adopt a characteristic crescent body shape.

Percentage of paralysed worms increases with levamisole concentration after 1 hr exposure.

Cost-Effective

Reduce research costs with our efficient C. elegans-based assays.

Time-Efficient

Rapidly assess neurological function with our streamlined approach.

Translatable

Gain insights applicable to human neurodegenerative conditions.

Customisable

Tailor assays to specific research needs for comprehensive results.

Partner with Us

Collaborate with Magnitude Biosciences to accelerate your neuroprotective research. Our manual paralysis assay offers a streamlined, cost-effective approach to evaluate compound efficacy.