With an aging population globally, the demand for research in this area is expanding and the pressure is on to find therapies that can be shown to slow the effects of ageing. However, finding out if your compounds actually work to slow ageing and looking at the potential impact on patient quality of life is challenging and complex.
In vitro studies aren’t sufficient to show the impact on ageing, and it’s historically difficult to test for ageing on physiological models; researchers would typically have to do these studies on rodents or other mammals as they age but experiments are complex and involve very long timelines.
Conversely, if you have a drug you know has an impact on slowing ageing, but don’t understand how it works to do this, it’s very challenging to design a study to determine this mode of action and understand the target ID.
Ageing is a complex and heterogeneous process, so using natural models of ageing in whole organisms and large test populations is the best approach to study ageing.
When you want to understand whether your compound shows efficacy to slow ageing, C. elegans, combined with our unique Healthspan automated imaging technology and team of ageing experts, is a fast and reliable model.
When you know your compound has efficacy to slow ageing but don’t know what the target is or don’t understand the mechanism by which it slows ageing, C. elegans is also a powerful tool to understand the mode of action. We can use transgenics to knock out, modify, or insert genes and combine this with our Healthspan technology to understand whether those genes are responsible for the ageing-slowing impact of your compound.
We provide the following benefits:
Take the jump from petri dish to in vivo models with confidence.
Helping industrial R&D get the data they need on their compounds in as little as three weeks.
Fast-track your preclinical research and de-risk high-investment rodent studies.
High-quality C. elegans lab services and machine leasing of our unique automated technology to help you stay top of your field.