Leaky Gut Assay with C. elegans

Advancing research in gut permeability

Leaky gut, characterized by increased intestinal permeability, is a condition where the intestinal barrier becomes compromised, allowing harmful substances to pass into the bloodstream. This syndrome intensifies with age, contributing to microbial imbalances, metabolic shifts, systemic health deterioration, and increased mortality.

The Challenge:

Current research on leaky gut relies heavily on rodent models, which are costly, time-consuming, and often lack translatability to human conditions. There's a pressing need for simpler, more cost-effective assays using robust models to comprehensively understand leaky gut pathogenesis and develop targeted treatment strategies.

Our Solution:

At Magnitude Biosciences, we've pioneered a breakthrough approach using C. elegans, a transparent and simple animal model, to study leaky gut phenotypes. The rapid life cycle of C. elegans is ideal for investigating gut integrity, especially in ageing populations. Like mammals, C. elegans possesses a distinct gut epithelial barrier, making it a powerful tool to explore leaky gut pathogenesis and develop innovative treatment modalities.

Leaky Gut Assay:

Our Leaky Gut assay leverages C. elegans to evaluate the efficacy of your products in maintaining intestinal barrier integrity during the ageing process. Using this assay, we can assess shifts in gut permeability and provide critical insights for developing interventions to combat leaky gut syndrome.

Young worms (Day 1) show no leakage of blue dye outside the gut.

Old worms (Day 18) exhibit leakage outside the gut cavity.

Partner with us for Gut Health research:

Join us in advancing gut health research and longevity. Our Gut Health assay, coupled with cutting-edge technologies, enables precise evaluations of compound efficacy in maintaining intestinal barrier function during ageing.

Key Benefits

  • Cost-Effective: Reduce research costs with our efficient C. elegans-based assays.
  • Time-Efficient: Rapidly assess gut integrity shifts with our streamlined approach.
  • Translatability: Gain insights directly applicable to human conditions.
  • Customizable: Tailor assays to specific research needs for comprehensive results.

Learn More

Contact us today to explore how our assays can benefit your research and product development efforts focused on gut health and longevity.

Get in touch today to find out how we can 
support you to accelerate your research

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SERVICES

Contract lab services for your research area

Our customised C. elegans studies help industry leaders generate high-quality, 
reproducible data to answer their research questions in these areas.

Microbiome

A powerful whole
organism model for
microbiome research

Neurodegeneration

A proven whole organism model for neurodegenerative disease
research

Toxicity

A powerful whole organism model for detecting toxicity for the environment and human health

Ageing

A powerful whole
organism model for accelerating ageing research

Transgenics

We can generate C. elegans strains tailored to the exact needs of your project.

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Ageing

A powerful whole
organism model for accelerating ageing research

Slide
Microbiome

A powerful whole organism model for
microbiome research

Slide
Neurodegeneration

A proven whole organism model for neurodegenerative disease
research

Slide
Toxicity

A powerful whole organism model for detecting toxicity for the environment and human health

Slide
Transgenics

We can generate C. elegans strains tailored to the exact needs of your project.

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