Fat Deposition Assay

Investigating weight management and metabolism with C. elegans

Fat plays critical roles in energy regulation, metabolic health, and disease susceptibility. Age-related shifts in fat distribution contribute to metabolic disorders and chronic inflammatory conditions, highlighting the importance of studying fat deposition in ageing organisms.

The Challenge:

Conventional rodent models used in fat deposition research are expensive, time-consuming, and present limitations in scalability. Addressing obesity and related metabolic disorders requires innovative animal models and efficient assays.

Our Solution:

Magnitude Biosciences offers a cutting-edge Fat Deposition Assay using C. elegans, a model organism that mirrors human fat redistribution with age.
C. elegans is a good translatable model to investigate fat regulation and food-related behaviours.

Our Fat Deposition Assay:

Our Fat Deposition Assay involves culturing C. elegans on OP50 bacteria stained with Oil Red O, allowing visualization and quantification of fat accumulation. We examine the effects of test compounds on fat deposition and metabolic health using microscopy imaging and absorbance analysis.

Oil Red straining for visualising fat deposition:

Starved worms

Fed worms

Discover if your product:

Has weight loss properties

Has a mechanism of action linked to dietary restriction

Affects energy metabolism

Has effects against worms on a hyperglycaemic diet

Key benefits:

Cost-Effective

Reduce research costs with our efficient C. elegans-based assays.

Time-Efficient

Rapidly assess cognition with automated technology.

Translatable

Gain insights applicable to age-related neurodegenerative conditions in humans.

Customisable

Tailor assays to specific research needs for comprehensive results.

Fat deposition quantified by image analysis

Partner with us for Weight Management Research

Collaborate with Magnitude Biosciences to advance your anti-obesity research and develop effective therapeutic interventions. Our assay streamlines research processes and accelerates drug discovery efforts aimed at combating obesity-related conditions.