We believe our technology can transform your science

Here’s how:

Manual assays are the traditional way of measuring ageing and toxicity in C. elegans, but they cannot cope with higher demands for throughput efficiency and data reproducibility.

Manual C. elegans lifespans assays:

  • are very time-consuming, require skill and are subject to operator variation 
  • use only a few widely-spaced timepoints
  • disrupt the worms and their environment at each manipulation
  • give single data points (live/dead) not continuous (e. g. speed) data

 

The Magnitude Biosciences Solution: Automated imaging for health, not death 

  • High data reproducibility: manual preparation consistency, with a defined medium for bacterial growth and strict schedule for plate pouring, bacterial and worm culture, as well as automated imaging for standardised data acquisition and processing
  • Non-invasive data acquisition: no mechanical disruption, no abrupt light changes, no abrupt temperature changes
  • Exhaustive data acquisition: 32 worm culture plates per machine with up to 50 worms per plate, individual worm tracking images taken every 0.8 seconds for 160 seconds, repeated every 5 minutes up to 10 days

 

Expanded options for graphical representation and detection of intervention effects

 

 

 

Like the look of our data but not sure why we do it in worms rather than mice? Read on to learn why worms are best.

 

Can our technology help your specific field of research?

If ageing, neurodegeneration, microbiome-host interactions or toxicity are your thing, check out our Research Services page. 

And if you can’t find your assay in there, get in touch. We’re always excited to help our clients design the best custom project to answer their research question.