Analysis and Data
Bacterial folate synthesis inhibition by SMX, showing dose-dependent decline in moving worms over 14 days, with many more data points than manual lifespan assays (Virk et al., 2012; 400 worms per condition).
Exploration: Individual worm tracks over a set time period, showing control worms (left) explore more of their environment than test worms (right) (superimposed tracks of 20 worms).
Colour-coded segmentation of the worm population by speed, giving detailed age-related decline in mobility compared to average speed (400 worms per condition).
Mobility decline over 6 days of the human amyloid-beta1-42 muscle-expressing GMC101 strain, compared to the AM134 control strain (180 worms per condition, top: decline in the fraction of moving worms over time, bottom: mean moving hours for each worm over the whole time period).
Chemotaxis: Tracking of individual worms position over time from release site (green circle) to lawn site (yellow circle), to pinpoint the rapid dynamics of chemotaxis (60 worms total, collated over 4 plates of 15 worms each).
Like the look of our data but not sure why we do it in worms rather than mice? Read on to learn why worms are best.
Can our technology help your specific field of research?
If ageing, neurodegeneration, microbiome-host interactions or toxicity are your thing, check out our Research Services page.
And if you can’t find your assay in there, get in touch. We’re always excited to help our clients design the best custom project to answer their research question.