Neurodegeneration produces complex behavioural changes that have profound effects on human quality of life that cannot be replicated in in-vitro models.
However, for in-vivo studies, researchers often rely on models that show artificial degeneration in young animals and thus don’t replicate the changes you would find in a natural ageing model. For example, using mice to look at how neurodegeneration occurs as ageing animals age or to see the long-term effects of early life interventions is complex, time-consuming and costly.
The options to test compounds that could slow the degeneration of neurons in a naturally ageing organism are limited, particularly if you need to reach the next milestone of your research project quickly.
We can see the effects of your compound in a naturally ageing model in a matter of weeks. C. elegans are used to generate models of neurodegenerative disease through overexpression of human proteins implicated in neurodegenerative diseases, which leads to loss of function phenotypes that can be scored and used to test interventions. The strongest phenotypes have arisen from overexpression in muscle cells, which gives rise to paralysis. This phenotype is relatively straightforward, albeit tedious to assess manually. However, our automated data acquisition, strict scheduling of larval selection and the use of defined reagents, help us conduct experiments quickly and still achieve a high level of data reproducibility.
We provide the following benefits:
Download our poster: Developing a System to Quantify Efficacy of Neurodegeneration Therapeutics Using Automated Monitoring of C. elegans
Biotech
Biotech professionals must progress their drug discovery R&D timelines fast in
order to make the best use of their funding and IP. We help you take the jump from
petri dish to mammal in vivo models with confidence and more quickly than going straight
to rodent models.
Health and Manufacturing
Consumer goods, manufacturing and other industries investing in R&D want to put
the best quality, eco-friendly products out on the market. However, testing your
compounds for impact on environmental and human health can lead to overly complex,
ethically challenging and time-consuming studies with animal models. C. elegans offer
an ethical approach that can get the data you need on your compound in as little as three weeks.
Pharma
The pressure on drug developers is greater than ever and pharma need to look to
innovative new tools to stay ahead of the competition. C. elegans offer an NC3Rs-approved
avenue to fast-track preclinical research, to save you from or reduce your reliance on
high-investment rodent studies.
Academia
You want to progress your research and improve lab operations but access to the
right technologies, technological expertise and the time to juggle everything is
challenging. We offer high-quality C. elegans lab services, transgenics services,
and machine leasing of our unique automated technology to help you stay top of your field.
Take the jump from petri dish to in vivo models with confidence.
Helping industrial R&D get the data they need on their compounds in as little as three weeks.
Fast-track your preclinical research and de-risk high-investment rodent studies.
High-quality C. elegans lab services and machine leasing of our unique automated technology to help you stay top of your field.