Fat plays critical roles in energy regulation, metabolic health, and disease susceptibility. Age-related shifts in fat distribution contribute to metabolic disorders and chronic inflammatory conditions, highlighting the importance of studying fat deposition in ageing organisms.

The Challenge:

Conventional rodent models used in fat deposition research are expensive, time-consuming, and present limitations in scalability. Addressing obesity and related metabolic disorders requires innovative animal models and efficient assays.

Our Solution:

Magnitude Biosciences offers a cutting-edge Fat Deposition Assay using C. elegans, a model organism that mirrors human fat redistribution with age. C. elegans is a good translatable model to investigate fat regulation and food-related behaviours.

Leveraging our proprietary WormGazer™ technology, we provide:

• Rapid evaluation of weight loss properties and metabolic impacts.
• Detailed insights into fat deposition mechanisms and energy regulation.
• A cost-effective and scalable approach to anti-obesity drug discovery.

So you can discover if your product:

• Has weight loss properties
• Has a mechanism of action linked to dietary restriction
• Effects energy metabolism
• Has an effect against worms on a hyperglycaemic diet

Our Fat Deposition Assay:

Our Fat Deposition Assay involves culturing C. elegans on OP50 bacteria stained with Oil Red O, allowing visualization and quantification of fat accumulation. We examine the effects of test compounds on fat deposition and metabolic health using microscopy imaging and absorbance analysis.