Muscle Health Assay

Age-related muscle loss, known as sarcopenia, is an inherent part of the ageing process. Sarcopenia significantly contributes to frailty, immobility, and increased mortality in the elderly population. Current investigations primarily rely on costly and time-consuming rodent models, which presents challenges for efficient research into muscle health.

The Challenge:

The increasing elderly population and the pressing challenges associated with muscle function decline demand novel animal models and cost-effective, time-efficient assays. Simplifying research processes is crucial for developing therapeutic interventions for sarcopenia and related conditions.

Our Solution:

C. elegans serves as an exceptional model for studying ageing and muscle health. Similar to mammals, C. elegans exhibits a gradual loss of mobility and muscle function with age, reflecting muscle and neurotransmission defects. This model organism offers unique advantages, including a short lifespan, large sample size capability, and genetic manipulability.

Muscle Health Assay:

Using our proprietary automated WormGazer™ technology provides a screening platform to identify candidates that preserve worm motility with ageing. Our Muscle Health assay can then be used to study the in-depth effects of successful candidates.  

We assess muscle health by visualizing muscle fiber organization using myo-3::GFP worm strains, offering detailed insights into muscle structure changes during ageing.