Scaling up drug discovery in orders of magnitude
Out of every 10,000 compounds, only one reaches the market1.
Most fail due to a lack of efficacy or unexpected toxicity, leading to years of lost time and millions in wasted investment.
Typical Drug Discovery Pathway
At Magnitude Biosciences, we’re transforming the early stages of drug discovery by providing rapid, scalable in vivo screening using C. elegans.
Combining the power of C. elegans and the WormGazer® to solve the challenges of Drug Discovery
Challenge
Solution
High Costs
Screen drug libraries in-vivo for as little as £1 per compound
Long Timelines
In-vivo lifespan reports in weeks, not years
In vitro limitations
Utilise the significant transability of C. elegans to find more hits and leads reliably
In vivo limitations
No regulatory requirements, faster and cheaper.
Accelerating the Drug Discovery Pipeline with C. elegans
Why use C. elegans for Drug Discovery?
Scientific Value: An established, predictive model that’s won four Nobel Prizes, C. elegans is a proven tool for biomedical research.
Human Translatability: With 60–80% gene conservation and high homology to human proteins and cellular pathways, C. elegans provides valuable insights relevant to human biology.
Speed & Cost Efficiency: A rapid 2–3 week lifespan enables faster results compared to rodent studies, delivering whole-organism data at a fraction of the cost.
Scalability: Our WormGazer® platform supports high-throughput testing with C. elegans, making it ideal for screening thousands of compounds.
Regulatory & Ethical Compliance: No regulatory restrictions or ethical concerns, fully 3R-compliant, and highly sustainable.
Unlike in vitro models, C. elegans allows you to understand drug effects in a naturally aging, whole-organism in vivo system, providing more reliable, translatable results.
Average Timeline of Pre-Clinical Models
Our Screening Platforms
Three levels of screening designed to meet your specific needs:
Estimate the cost of your project:
The Advantages of High Throughput Screening Powered By C. elegans & WormGazer®
Cost-Effective: Maximise data, from just $1 a compound
Scalable Automation: Screen 100,000s of compounds
Rapid Turnaround: Actionable data in 7 days
In Vivo Accuracy: Highly translatable efficacy and tox data
Regulation-Free Testing: 3R compliant ethical model
We have different WormGazer® platforms to suit the throughput you need from 10s to 1,000,000s
Sliding scale price range from $1 to $4,000 per compound depending on the richness of data and the rate of compound attrition you need
We offer multiple entry points for your compounds throughout the development pipeline
Or combine our platforms for an end-to-end service from screening to lead candidates ID
Why Magnitude Biosciences?
We take a hands on and collaborative approach to our projects, offering support from study design to data interpretation and presentation.
Get in touch today to find out how we can support you to accelerate your research
Sign up to our newsletter today, to get access to the latest company and industry news
