Age-related Cognitive Functional Decline Assay

Measuring decline in neuronal function with age

C. elegans, with its well-mapped nervous system and neurotransmitter similarities to humans, presents a unique model for studying age-related cognitive decline. The decline in dopaminergic responses associated with ageing mirrors conditions like Parkinson’s disease (PD) in humans.

The Challenge:

Current behavioural assays using rodents for studying cognitive decline are expensive, time-consuming, and lack translatability to human conditions, hindering progress in anti-ageing therapeutic development.

Our Solution:

Magnitude Biosciences leverages C. elegans and our proprietary WormGazer^TM technology to provide our novel Age-related Cognitive (ARC) Functional Assay. This assay quantifies cognitive decline in aged worms and neurodegenerative disease models, offering a cost-effective and efficient alternative to rodent models.

The ARC Assay:

Our ARC assay measures cognitive function through a chemotaxis-dependent behavior that declines with age. By automating data acquisition with our WormGazer^TMtechnology, we can evaluate the effects of compounds on cognitive health in C. elegans.

Control

Normal mobility & exploration

Can recognises food source & stay near it

Disease A

Normal mobility & exploration

Impaired cognitive function results in failure to recognise and move towards food

Disease B

Impaired mobility & exploration

Can recognise food source & stay near it

Worms of various ages are placed a fixed distance from their food source. As they age, it takes longer for them to find their food, and they are less able to cognitively localise themselves to the food.

Partner with Us for Neuronal Function Research

Collaborate with Magnitude Biosciences to accelerate your research on age-related cognitive decline. Our ARC assay provides a streamlined approach to assess compound efficacy.

Key Benefits

Cost-Effective: Reduce research costs with efficient C. elegans-based assays.
Time-Efficient: Rapidly assess cognitive function with automated technology.
Translatability: Gain insights directly applicable to age-related neurodegenerative conditions.
Customizable: Tailor assays to specific research needs for comprehensive results.

Learn More

Contact us today to explore how our ARC assay can advance your research on age-related cognitive decline and support the development of anti-ageing therapeutics.