Leveraging Caenorhabditis elegans as an in vivo model offers a powerful approach to studying biofilm formation and pathogenic infections to counteract anti-microbial resistance, a global health problem

In this study, we show how C. elegans can efficiently model multi-drug resistant Pseudomonas aeruginosa infections, enabling real-time visualisation of infection progression and its effects on host survival and healthspan.

This scalable model offers both whole-organism phenotypic readouts and mechanistic insights into bacterial virulence, making it a valuable alternative to traditional in vitro approaches for rapid antimicrobial screening.

C. elegans also serves as a high-throughput platform for identifying new antimicrobial compounds, accelerating efforts to combat resistant bacterial and biofilm-related infections

Read the full paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC11683784/